Cerca nel sito

Per ricevere info:

Email:
Nome:
Dove si terranno le prossime olimpiadi estive?

Informazioni:

Ufficio CUS Insubria:
Via Monte Generoso 59 · Varese

Palazzetto Sportivo

cus@uninsubria.it
cusinsubria@legalmail.it
tel · 0332 219895

tel · 0332 219896

fax · 0332 219898


Sede legale:
Via Ravasi 2 · Varese

CF 95029780129

PIVA02501940122


 
 

facebook

foto

youtube

twitter


Prof. Alberto Passi
Delegato del Rettore Insubria Varese

Contact
Via Dunant 5
Varese
21100
Italia

CLOAKING
0332 217142
0332 217119

Professore ordinario di biochimica
Dipartimento di Scienze Chirurgiche e Morfologiche (DSCM)
Università dell’Insubria - Varese


FORMAZIONE:
1995 SpecialitĂ  in Biochimica Clinica, UniversitĂ  di Pavia.
1992 Dottorato in Biochimica, Dipartimento di Biochimica, UniversitĂ  di Pavia e Genova.
1987 Laurea in Medicina e Chirurgia, UniversitĂ  di Pavia.


FORMAZIONE ADDIZIONALE:
Studente presso Maximilianeum Stiftung di Monaco (Germania) (1982 )
Research Fellow, in Chemical Morphology UniversitĂ  di Manchester (Inghilterra) (1990)


INCARICHI ACADEMICI:
(2011-ogi) Professore ordinario di biochimica, DSCM, Università dell’Insubria, Varese.
(2008-2011) Professore ordinario di biochimica, DSBSC, Università dell’Insubria, Varese.
(2001-2007) Professore associato di biochimica, DSBSC, Università dell’Insubria, Varese.
(1998-2001) Ricercatore di biochimica, DSBSC, Università dell’Insubria, Varese.
(1992-1998) Ricercatore di biochimica, Dipartimento di biochimica UniversitĂ  di Pavia.

ULTERIORE ESPERIENZA:
Research Scholar Cleveland Clinic Foundation (OH– USA) (2000-2001)
Postdoctoral fellow Dipartimento di Biochimica UniversitĂ  di Pavia (1991-1992)
Studente di dottorato Dipartimento di Biochimica UniversitĂ  di Pavia e Genova (1988-1991)
Servizio militare Aeronautica (1987-88).

INCARICHI CLINICI:
Medico di Pronto soccorso (1989-1992)

SOCIETA’ SCIENTIFICHE:
SocietĂ  Italiana di Biochimica e Biologia Molecolare (SIBBM) (1990-oggi)
SocietĂ  Italiana per lo Studio del Tessuto Connettivo (SISC) (1990-oggi).
SocietĂ  Internazionale della Biologia della Matrice (1998-present)
SocietĂ  Americana della Biologia della Matrice (2003-present)
SocietĂ  Americana di Biochimica e Biologia Molecolare (ASBMB) (2006-present)

PREMI:
SocietĂ  Ellenica di Biochimica (2009)
Alumnus del Collegio Ghislieri , Pavia, (1981-1987)

ALBO PROFESSIONALE:
1988-oggi, Iscrizione all’albo professionale dei Medici e Chirurghi.

RESPONSABILITĂ  ACCADEMICHE:
Presidente del corso di laurea in scienze motorie (Università dell’Insubria)
Direttore del centro di biotecnologie per la salute umana (Università dell’Insubria)
Delegato del rettore per le attività sportive (Università dell’Insubria)
Delegato del rettore per gli le relazioni internazionali (Università dell’Insubria)
Consigliere del Ministro Greco dell’Università e degli affari religiosi.
Componente del CUS dei Laghi (Varese-Como)

COMITATO EDITORIALE:
- Editor DEL Journal of Biological Chemistry (2011-2016)
- Associate Editor DEL Connective Tissue Research
- Editor DELL’Open Biology Journal
- Editor di Frontiers in membrane physiology and biophysics

PARTECIPAZIONE A CONGRESSI INTERNAZIONALI NEGLI ULTIMI 5 ANNI:
1. Proteoglycan and cell signalling, Harden Discussion, Runo, Sweden, 2005
2. XVIII Glyco Conference, Florence (Italy), 2005 (selected talk)
3. Gordon Conference on Proteoglycans, Andover NH USA, 2006
4. XX FECTS Meeting, Oulu (Finland) 2006 (selected talk)
5. Hyaluronan 2007, Charleston (SC-USA) (selected talk)
6. FEBS Selected Course, Matrix Pathobiology, Patras (Greece) May 2007 (invited speaker)
7. Carla Workshop of Fabre Laboratories, Soreze (France) 2007 (invited speaker)
8. 4th Finnish Glycoscience Symposium, Rautavaara (Finland) 2007 (invited speaker)
9. Gordon Conference on Proteoglycans, Andover NH USA, 2008 (invited speaker)
10. FEBS-IUMB Athens (GREECE) 2008 (selected talk)
11. International Conference on Cancer, Heraklion (Greece) 2008. (Invited speaker)
12. FEBS Selected Course, Matrix Pathobiology, Patras (Greece) July 2009 (invited speaker)
13. Hellenic Society of Biochemistry and Molecular Biology Extracellular matrix club: national
meeting Patras (Greece) July 2009 (invited speaker).
14. Hyaluronan 2010, Kyoto (Japan) June 2010 (invited speaker)
15. Experimental Biology Meeting EB 2011, Washington (USA)
16. FEBS Selected Course, Matrix Pathobiology, Spetses (Greece) September 2011 (invited
speaker)
17. Experimental Biology Meeting EB 2012, San Diego (USA)
18. Brazilian Society of Biochemistry meeting –SBBq Foz Uguazù (Brazil) 2012 (Invited speaker)

ARGOMENTI DI RICERCA NEGLI ULTIMI 5 ANNI:
1992-oggi. Metabolismo della matice extracellulare.
1993-oggi Effetti antiossidanti dei proteoglicani.
2000-oggi Metabolismo dell’acido ialuronico in tessuti sani e patologici .

BIBLIOGRAFIA:
A. Passi è autore di 75 articoli in extensor su riviste indicizzate con valutatori anonimi esterni. Il fattore di
impatto totale super 250 e h index di 20. In oltre 40 congressi internazionali ha presentato lavori e relazioni.
Ha tenuto seminari in varie UniversitĂ  estere tra cui UniversitĂ  di Berna (Svizzera), NY University (USA),
University of Harvard (USA), Cleveland Clinic Foundation (USA), Open University (UK), UniversitĂ  di
Kuopio (Finlandia), UniversitĂ  di Uppsala (Svezia), UniversitĂ  di Patrasso (Grecia), UniversitĂ  di Muenster
(Germania).

ARTICOLI PRINCIPALI NEGLI ULTIMI 5 ANNI:
1. Moriondo A, Marcozzi C, Bianchin F, Reguzzoni M, Severgnini P, Protasoni M, Raspanti
M, Passi A, Pelosi P, Negrini D. Impact of mechanical ventilation and fluid load on
pulmonary glycosaminoglycans. Respir Physiol Neurobiol. 2012 May 31;181(3):308-20.

2. Piccioni F, Malvicini M, Garcia MG, Rodriguez A, Atorrasagasti C, Kippes N, Piedra
Buena IT, Rizzo MM, Bayo J, Aquino J, Viola M, Passi A, Alaniz L, Mazzolini G.
Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic
hepatocellular carcinoma model in mice. Glycobiology. 2012 Mar;22(3):400-10.

3. Vigetti D, Rizzi M, Moretto P, Deleonibus S, Dreyfuss JM, Karousou E, Viola M, Clerici
M, Hascall VC, Ramoni MF, De Luca G, Passi A. Glycosaminoglycans and glucose prevent
apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells. J Biol
Chem. 2011 Oct 7;286(40):34497-503.

4. Merrilees MJ, Beaumont BW, Braun KR, Thomas AC, Kang I, Hinek A, Passi A, Wight
TN. Neointima formed by arterial smooth muscle cells expressing versican variant V3 is
resistant to lipid and macrophage accumulation. Arterioscler Thromb Vasc Biol. 2011
Jun;31(6):1309-16.

5. Moriondo A, Marcozzi C, Bianchin F, Passi A, Boschetti F, Lattanzio S, Severgnini P,
Pelosi P, Negrini D. Impact of respiratory pattern on lung mechanics and interstitial
proteoglycans in spontaneously breathing anaesthetized healthy rats. Acta Physiol (Oxf).
2011 Oct;203(2):331-41.

6. Tammi RH, Passi AG, Rilla K, Karousou E, Vigetti D, Makkonen K, Tammi MI.
Transcriptional and postranslational regulation of hyaluronan synthesis. FEBS J. 2011;
278(9):1419-28.

7. Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, Bonetti P, Lualdi M, Vidalino
L, Fabbri M, Sacco MG, van Rooijen N, Campomenosi P, Vigetti D, Passi A, Riva C,
Capella C, Sanvito F, Doglioni C, Gribaldo L, Macchi P, Sica A, Noonan DM, Ghia P,
Taramelli R. Microenvironmental control of malignancy exerted by RNASET2, a widely
conserved extracellular RNase. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1104-9.

8. Vigetti D, Clerici M, Deleonibus S, Karousou E, Viola M, Moretto P, Heldin P, Hascall VC,
De Luca G, Passi A. Hyaluronan synthesis is inhibited by adenosine monophosphate
activated protein kinase through the regulation of Hyaluronan synthase 2 activity in human
aortic smooth muscle cells. J Biol Chem. 2011 286(10):7917-24

9. Karangelis DE, Kanakis I, Asimakopoulou AP, Karousou E, Passi A, Theocharis AD,
Triposkiadis F, Tsilimingas NB, Karamanos NK. Glycosaminoglycans as key molecules in
atherosclerosis: the role of versican and hyaluronan. Curr Med Chem. 2010;17(33):4018-26.

10. Vigetti D, Genasetti A, Karousou E, Viola M, Moretto P, Clerici M, Deleonibus S, De Luca
G, Hascall VC, Passi A. Proinflammatory cytokines induce Hyaluronan synthesis and
monocyte adhesion in human endothelial cells through Hyaluronan synthase 2 (HAS2) and
the nuclear factor-kappaB (NF-kappaB) pathway. J Biol Chem.2010 Aug 6;285(32):24639-45.

11. Karousou E, Kamiryo M, Skandalis SS, Ruusala A, Asteriou T, Passi A, Yamashita H,
Hellman U, Heldin CH, Heldin P. The activity of hyaluronan synthase 2 is regulated by
dimerization and ubiquitination. J Biol Chem.2010 Aug 6;285(32):24639-45.

12. Gualeni B, Facchini M, De Leonardis F, Tenni R, Cetta G, Viola M, Passi A, Superti-Furga
A, Forlino A, Rossi A. Defective proteoglycan sulfation of the growth plate zones causes
reduced chondrocyte proliferation via an altered Indian hedgehog signalling. Matrix Biol.
2010 Jul;29(6):453-60.

13. Karousou E, Ronga M, Vigetti D, Barcolli D, Passi A, Maffulli N. Molecular interactions in
extracellular matrix of tendon. Front Biosci (Elite Ed). 2010 Jan 1;2:1-12.

14. Vigetti D, Genasetti A, Karousou E, Viola M, Clerici M, Bartolini B, Moretto P, De Luca G,
Hascall VC, Passi A. Modulation of hyaluronan synthase activity in cellular membrane
fractions. J Biol Chem. 2009 Oct 30;284(44):30684-94.

15. Tajana MS, Murena L, Valli F, Passi A, Grassi FA. Correlations between biochemical
markers in the synovial fluid and severity of rotator cuff disease. Chir Organi Mov. 2009
Apr;93 Suppl 1:S41-8.

16. Vigetti D, Rizzi M, Viola M, Karousou E, Genasetti A, Clerici M, Bartolini B, Hascall VC,
De Luca G, Passi A. The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2
activity, proliferation, and motility of human aortic smooth muscle cells. Glycobiology.
2009 May;19(5):537-46.

17. Cordo-Russo R, Garcia MG, Barrientos G, Orsal AS, Viola M, Moschansky P, Ringel F,
Passi A, Alaniz L, Hajos S, Blois SM. Murine abortion is associated with enhanced
hyaluronan expression and abnormal localization at the fetomaternal interface. Placenta.
2009 Jan;30(1):88-95.

18. Vigetti D, Viola M, Karousou E, Genasetti A, Rizzi M, Clerici M, Bartolini B, Moretto P,
De Luca G, Passi A. Vascular pathology and the role of hyaluronan.
ScientificWorldJournal. 2008 Nov 2;8:1116-8.

19. Vigetti D, Andrini O, Clerici M, Negrini D, Passi A, Moriondo A. Chondroitin sulfates act
as extracellular gating modifiers on voltage-dependent ion channels. Cell Physiol Biochem.
2008;22(1-4):137-46.

20. Pirrone F, Mazzola SM, Pastore C, Paltrinieri S, Sironi G, Riccaboni P, Viola M, Passi A,
Clement MG, Albertini M. Activated protein C protection from lung inflammation in
endotoxin-induced injury. Exp Biol Med (Maywood). 2008 Nov;233(11):1462-8.

21. Vigetti D, Moretto P, Viola M, Genasetti A, Rizzi M, Karousou E, Clerici M, Bartolini B,
Pallotti F, De Luca G, Passi A. Aortic smooth muscle cells migration and the role of
metalloproteinases and hyaluronan. Connect Tissue Res.2008;49(3):189-92.

22. Genasetti A, Vigetti D, Viola M, Karousou E, Moretto P, Rizzi M, Bartolini B, Clerici M,
Pallotti F, De Luca G, Passi A. Hyaluronan and human endothelial cell behavior. Connect
Tissue Res. 2008;49(3):120-3.

23. Viola M, Vigetti D, Genasetti A, Rizzi M, Karousou E, Moretto P, Clerici M, Bartolini B,
Pallotti F, De Luca G, Passi A. Molecular control of the hyaluronan biosynthesis. Connect
Tissue Res. 2008;49(3):111-4.

24. Viola M, Vigetti D, Karousou E, Bartolini B, Genasetti A, Rizzi M, Clerici M, Pallotti F, De
Luca G, Passi A. New electrophoretic and chromatographic techniques for analysis of
heparin and heparan sulfate. Electrophoresis. 2008 Aug;29(15):3168-74.

25. Karousou E, Ronga M, Vigetti D, Passi A, Maffulli N. Collagens, proteoglycans, MMP-2,
MMP-9 and TIMPs in human achilles tendon rupture. Clin Orthop Relat Res. 2008
Jul;466(7):1577-82.

26. Negrini D, Passi A, Moriondo A. The role of proteoglycans in pulmonary edema
development. Intensive Care Med. 2008 Apr;34(4):610-8.

27. Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, Clerici M, Hascall VC,
De Luca G, Passi A. Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell
motility during aging. J Biol Chem. 2008 Feb 15;283(7):4448-58.

28. Genasetti A, Valentino ML, Carelli V, Vigetti D, Viola M, Karousou EG, Melzi d'Eril GV,
De Luca G, Passi A, Pallotti F. Assessing heteroplasmic load in Leber's hereditary optic
neuropathy mutation 3460G->A/MT-ND1 with a real-time PCR quantitative approach. J
Mol Diagn. 2007 Sep;9(4):538-45.

29. Pelosi P, Rocco PR, Negrini D, Passi A. The extracellular matrix of the lung and its role in
edema formation. An Acad Bras Cienc. 2007 Jun;79(2):285-97.

30. Moriondo A, Pelosi P, Passi A, Viola M, Marcozzi C, Severgnini P, Ottani V, Quaranta M,
Negrini D. Proteoglycan fragmentation and respiratory mechanics in mechanically
ventilated healthy rats. J Appl Physiol. 2007 Sep;103(3):747-56.

31. Negrini D, Passi A. Interstitial matrix and transendothelial fluxes in normal lung. Respir
Physiol Neurobiol. 2007 Dec 15;159(3):301-10.

32. Vigetti D, Moretto P, Viola M, Genasetti A, Rizzi M, Karousou E, Pallotti F, De Luca G,
Passi A. Matrix metalloproteinase 2 and tissue inhibitors of metalloproteinases regulate
human aortic smooth muscle cell migration during in vitro aging. FASEB J. 2006
Jun;20(8):1118-30.

33. Mattarucchi E, Marsoni M, Passi A, Lo Curto F, Pasquali F, Porta G. Establishment and
study of different real-time polymerase chain reaction assays for the quantification of cells
with deletions of chromosome 7. J Mol Diagn. 2006 May;8(2):218-24.

34. Uccella S, Cerutti R, Vigetti D, Furlan D, Oldrini R, Carnevali I, Pelosi G, La Rosa S, Passi
A, Capella C. Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine
transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene
expression analysis. J Histochem Cytochem. 2006 Aug;54(8):863-75.

35. Vigetti D, Ori M, Viola M, Genasetti A, Karousou E, Rizzi M, Pallotti F, Nardi I, Hascall
VC, De Luca G, Passi A. Molecular cloning and characterization of UDP-glucose
dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan
synthesis. J Biol Chem. 2006 Mar 24;281(12):8254-63.

36. Viola M, Karousou EG, Vigetti D, Genasetti A, Pallotti F, Guidetti GF, Tira E, De Luca G,
Passi A. Decorin from different bovine tissues: study of glycosaminoglycan chain by
PAGEFS. J Pharm Biomed Anal. 2006 Apr 11;41(1):36-42.

37. Negrini D, Tenstad O, Passi A, Wiig H. Differential degradation of matrix proteoglycans
and edema development in rabbit lung. Am J Physiol Lung Cell Mol Physiol. 2006
Mar;290(3):L470-7.

 
Download information as a VCard